His comments come as Premier League clubs are preparing to discuss proposals for Project Restart in an attempt to try to salvage the remaining games of the 2019/20 season.
The campaign has been suspended since 13 March and while clubs want to finish the season, Aguero, who has been spending lockdown in his Cheshire home, believes players are reluctant.
“The majority of players are scared because they have children and families,” Aguero told Argentinian TV station El Chiringuito.
“I’m scared but I’m with my girlfriend here and I’m not going to be in contact with other people. I’m locked in my house and the only person I could infect is my girlfriend.
“They’re saying that there are people that have it and don’t have any symptoms but still infect you. That’s why I am here at home. Maybe I have the illness and I don’t even know.
“When one person is ill we will think ‘oh what’s happening here?’ I hope a vaccine will be found soon so that this all ends.”
The government is due to review lockdown restrictions next Thursday and Project Restart could see matches being played behind closed doors from 8 June, with players asked to wear face masks at all times.
There is a possibility some matches will be available on free-to-air TV.